设计合成了14个含1,2,4-噻二唑环的甲氧丙烯酸酯类新化合物,其结构经红外、电喷雾串联质谱(ESI-MS)和核磁共振氢谱确证。生物活性测定结果表明,化合物7j、7k、7m、7n在100 mg/L质量浓度下对小麦赤霉病菌等6种供试病原菌均有较高抑菌活性,其中7i对小麦赤霉病菌Fusarium graminearum的抑菌率为100%。 14 novel 1,2,4-thiadiazole-containing methoxyacrylates were designed and synthesized. Their structures were confirmed by IR, ESI-MS and 1H-NMR. The bioassay results showed that the compounds 7j, 7k, 7m and 7n had high antibacterial activity against 6 tested pathogenic fungi such as Fusarium graminearum at a concentration of 100 mg / L, of which 7i had the highest inhibitory activity against Fusarium graminearum The antibacterial rate was 100%.