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小枝链霉菌(Str.ramulcsus)Tue-34及其产生的丙酮霉素(Acetomycin)在1958年被H.Zahner等报道。后用化学筛选法发现该产生菌还产生一系列与Ehrlich、Barrollier及 Tetrazolblau试剂呈颜色反应的代谢产物。其中有四个组分被分离为纯品并测定了结构,分别命名为 Tue-34-D、H、M、N。 34-D和H属于友菌素-褶皱菌素(Amicetin-Plicacetin)族抗生素。34-H的结构是3’-hydroxylplicacetin,故定名为Oxyplicacetin。34-M(Ⅱ)、N(Ⅰ)则属于β-氧代色胺衍生物。以下报道它们的结构研究。
Str.ramulculus Tue-34 and its produced Acetomycin were reported by H. Zahner et al in 1958. After the chemical screening method was found that the bacteria also produce a series of Ehrlich, Barrollier and Tetrazolblau reagent color reaction metabolites. Four of these components were isolated as pure and their structures were determined and named Tue-34-D, H, M, N, respectively. 34-D and H belong to the Amicetin-Plicacetin family of antibiotics. 34-H structure is 3’-hydroxylplicacetin, it is named Oxyplicacetin. 34-M (Ⅱ), N (Ⅰ) belong to β-oxo-tryptamine derivatives. Their structural studies are reported below.