论文部分内容阅读
以4-[(2,2’∶6’,2″-二吡啶基)-4-吡啶]-N,N-二乙基苯胺作为活性配体,合成了新型Co(Ⅱ)配合物[Co_2(μ-Cl)_2Cl_2L2][CoLCl_2](CH_3CH_2OH)_2。通过X-单晶衍射、质谱、红外、元素分析等方法对其结构进行表征。从MTT实验可以看出,相对于人正常肝细胞HL-7702,目标化合物对BEL-7404、T-24、A549、MGC80-3等肿瘤细胞有较好的抑制作用,其IC_(50)范围为6.69~20.24μmol/L,尤其是对T-24细胞,IC_(50)值为6.69(±1.09)μmol/L,其活性约为顺铂的3倍。
A novel Co (Ⅱ) complex [Co_2] has been synthesized using 4 - [(2,2’-6 ’, 2 "-dipyridinyl) -4- pyridine] -N, (μ-Cl) _2Cl_2L2] [CoLCl_2] (CH_3CH_2OH) _2. Its structure was characterized by X-ray single crystal diffraction, mass spectrometry, infrared spectroscopy and elemental analysis etc. It can be seen from the MTT experiment that compared with the normal human hepatocyte HL -7702, the target compound has good inhibitory effect on tumor cells such as BEL-7404, T-24, A549 and MGC80-3, and the IC 50 ranged from 6.69 to 20.24 μmol / L, especially to T-24 cells , The value of IC 50 was 6.69 (± 1.09) μmol / L, its activity was about 3 times of cisplatin.