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IgG4应答被认为是源于长期或反复接触特定抗原的结果。因此,对能够抵抗金黄色葡萄球菌的特异性IgG4抗体应答的研究,可能使人们对宿主与病原体的相互作用以及微生物毒力因子有一个全新的思考。利用流式细胞术分析技术,我们对来源于健康的持续鼻腔带菌者,健康的持续非携带者以及三个不同国家多种葡萄球菌感染患者的血清进行检测,结果检测到针对40种不同金黄色葡萄球菌毒力因子的全部IgG(IgGt)、IgG1和IgG4抗体应答。
The IgG4 response is thought to result from the long-term or repeated exposure to a particular antigen. Therefore, the study of the specific IgG4 antibody response against Staphylococcus aureus may give rise to a new consideration for host-pathogen interactions and microbial virulence factors. Using flow cytometry analysis, we tested sera from healthy, persistent nasal carriers, healthy continuing non-carriers, and patients with multiple staphylococcal infections in three different countries and found that 40 different gold-colored Staphylococcal virulence factor total IgG (IgGt), IgG1 and IgG4 antibody responses.