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应用聚乙二醇(PEG)6000(2)和号丙烯酸树脂(3)为混和载体,用溶剂法制备了盐酸尼卡地平(1)肠溶缓释固体分散体。差热分析和X射线粉末衍射证实药物以分子状态分散于载体中。药物的释放速度受药物和载体3的比例、载体中2的含量、固体分散体粒子的大小、溶出介质的影响。稳定性实验表明,固体分散体贮存3个月后,溶出速度略有下降,药物的分散状态没有明显改变。
The solution of nicardipine hydrochloride (1) enteric sustained-release solid dispersion was prepared by solvent method using polyethylene glycol (PEG) 6000 (2) and acrylic resin (3) as mixed carrier. Differential thermal analysis and X-ray powder diffraction confirmed that the drug was dispersed in the carrier in a molecular state. The release rate of the drug is influenced by the ratio of the drug to the carrier 3, the amount of 2 in the carrier, the size of the particles of the solid dispersion, and the dissolution medium. Stability experiments show that the solid dispersion after storage for 3 months, the dissolution rate decreased slightly, the drug dispersion did not change significantly.