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探讨血管紧张素原 (AGT)基因M2 35T分子变异与哈萨克人原发性高血压 (EH)的关系 ,采用多聚酶链式反应法及限制性片段长度多态性技术 (PCR RFLP)对 132例EH(EH组 )及 75例正常者 (正常对照组 )进行AGT基因M2 35T多态性检测。新疆哈萨克族原发性高血压AGT基因型频率为TT :0 ,TM :4 1.6 7% ,MM :5 8.33% ;T2 35与M2 35等位基因频率分别 2 0 .83% ,79.17%。而对照组其相应频率分别为 0 ,4 6 .6 7% ,5 3.33% ;2 3.33% ,76 .6 7% ,两组相比无显著性差异 (P >0 .0 5 )。按性别分组后 ,男女等位基因频率两组相比亦无显著性差异 (P >0 .0 5 )。证明AGT基因M2 35T分子变异可能与哈萨克族人群高血压发病无关联
To explore the relationship between M235T molecular variation of angiotensinogen (AGT) gene and essential hypertension (EH) in Kazakh and to investigate the association between 132 EH (EH) and polymerase chain reaction-restriction fragment length polymorphism (PCR RFLP) (EH group) and 75 healthy controls (normal control group). The frequency of AGT genotypes in Kazaks of Xinjiang was TT: 0, TM: 41.77% and MM: 5: 8.33%, respectively. The frequencies of T235 and M235 alleles were 20.83% and 79.17%, respectively. The corresponding frequencies of the control group were 0, 46.67%, 5 3.33%, 23.33%, 76.67% respectively, with no significant difference between the two groups (P> 0.05). There were no significant differences in gender and allele frequency between the two groups (P> 0.05). Proved AGT gene M235T molecular variation may be related to the incidence of hypertension in Kazak population unrelated