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子宫内膜异位症(EMs)是一种雌激素依赖性疾病,雌激素效应除受血浆雌激素水平影响外,还取决于靶组织各因子及雌激素合成代谢相关酶的表达模式。其中包括雌激素受体(ER)α和β亚型、17HSD1和2、芳香化酶、前列腺素等因子。时其表达变化的深入理解是寻求EMs诊治手段的基础。就目前这些雌激素放应因子的研究状况进行综述。
Endometriosis (EMs) is an estrogen-dependent disease, estrogen effect in addition to the impact of plasma estrogen levels, but also depends on the target tissue factor and estrogen anabolic metabolism-related expression patterns. These include estrogen receptor (ER) alpha and beta subtypes, 17HSD1 and 2, aromatase, prostaglandin and other factors. In-depth understanding of the changes in expression is the basis for seeking the means of diagnosis and treatment of EMs. The current research status of estrogen-releasing factor is reviewed.