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目的分析他汀类药物对冠状动脉粥样硬化斑块的治疗体会。方法选取我院收治的82例冠状动脉粥样硬化患者,采用随机数字表法分为试验组(治疗使用瑞舒伐他汀)和对照组(治疗使用普伐他汀),每组各41人,连续治疗12个月,观察两组患者粥样硬化斑块的变化情况及两组患者治疗前后TC、LDL、HDL的水平变化。结果两组患者经过治疗后,TC、LDL、HDL水平较治疗前均有改善,且试验组改善效果更加显著;试验组患者粥样硬化斑块缩小幅度较对照组更为明显,两组数据差异较明显,具有统计学意义(P<0.05)。结论他汀类药物可延缓、阻断甚至逆转冠状动脉动脉粥样硬化斑块的进展,且瑞舒伐他汀的效果优于普伐他汀。
Objective To analyze the treatment of coronary atherosclerotic plaque by statins. Methods A total of 82 patients with coronary atherosclerosis admitted to our hospital were randomly divided into experimental group (treated with rosuvastatin) and control group (treated with pravastatin), with 41 patients in each group. Continuous After 12 months of treatment, the change of atherosclerotic plaques and the levels of TC, LDL and HDL in two groups before and after treatment were observed. Results After treatment, the levels of TC, LDL and HDL in both groups improved compared with that before treatment, and the improvement effect in the experimental group was more significant. The reduction of atherosclerotic plaque in the experimental group was more obvious than that in the control group, More obvious, with statistical significance (P <0.05). Conclusion Statins can delay, block or even reverse the progression of coronary atherosclerotic plaque, and rosuvastatin is better than pravastatin.