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目的探讨陕西省安康地区女性人群宫颈人乳头瘤病毒(HPV)感染亚型的分布特征。方法选择安康市中心医院9 006例女性,采用PCR导流杂交技术对HPV感染亚型进行分型检测,分析HPV感染亚型分布特征及各年龄段女性人群HPV感染状况。结果 9 006例女性中共检出HPV阳性1 957例,HPV感染总阳性率为21.73%。高危HPV亚型在各年龄段女性中均有较高的感染率,>60岁年龄组最高,41~50岁年龄组最低,各年龄组比较差异均有统计学意义(P<0.05)。各年龄段女性人群均以高危HPV亚型感染为主,低危亚型和高低危亚型混合感染率均较低,其变化曲线略呈低“V”字形。2 175例高危HPV感染女性中,单一感染和多重感染女性分别为1 306例和869例;377例低危HPV感染女性中,单一感染和多重感染女性分别为211例和166例。高危HPV感染较常见的亚型均依次为HPV16、HPV58、HPV52、HPV53、HPV39和HPV33,分别占单一和多重高危感染的78.94%(1 031/1 306)和75.08%(1 633/2 175);在低危HPV感染中,较常见的亚型均为HPV81、HPV11和HPV6,分别占单一和多重低危感染的95.73%(202/211)和93.90%(354/377)。最常见的单一和多重感染亚型分别为HPV16和HPV81。不同年龄段女性人群最常见的高危HPV感染亚型为HPV16。在不同年龄段女性人群中,均以单一感染为主。在多重感染中,二重感染最多见。结论陕西省安康地区女性人群HPV感染率较高,常见高危亚型为HPV16、HPV58、HPV52、HPV53、HPV39、HPV33,低危亚型为HPV81和HPV11。不同年龄段女性HPV感染亚型分布不同。不同年龄段女性高危和高低危HPV亚型混合感染率有显著差异。
Objective To investigate the distribution of HPV subtypes in female population in Ankang, Shaanxi Province. Methods A total of 9 006 women from Ankang Central Hospital were enrolled in this study. PCR was used to detect HPV subtypes. The distribution of HPV subtypes and the prevalence of HPV infection in women of all ages were analyzed. Results Nine hundred and sixty-six women were found to have HPV-positive 1 957 cases, the total positive rate of HPV infection was 21.73%. High-risk HPV subtypes had a higher infection rate in women of all ages, the highest in> 60 years old group, the lowest in 41 ~ 50 years old group, the difference was statistically significant in all age groups (P <0.05). The female population of all age groups were all infected with high-risk HPV subtype. The mixed infection rates of low-risk subtype and high-low subtype subtype were low, and their variation curves were slightly lower than “V” shape. Among 2 175 women with high-risk HPV infection, there were 1 306 and 869 women with single infection and multiple infection, respectively. Among 377 women with low-risk HPV infection, there were 211 and 166 women with single and multiple infections, respectively. The most common subtypes of high risk HPV infection were HPV16, HPV58, HPV52, HPV53, HPV39 and HPV33 in turn, accounting for 78.94% (1 031/1 306) and 75.08% (1 633/2 175) of single and multiple high- . Among low-risk HPV infections, the most common subtypes were HPV81, HPV11 and HPV6, accounting for 95.73% (202/211) and 93.90% (354/377) of single and multiple low-risk infections, respectively. The most common single and multiple subtypes of infection are HPV16 and HPV81, respectively. The most common high-risk HPV subtype in women of different ages is HPV16. In different age groups of women, are mainly single infection. In multiple infections, the most common double infection. Conclusion The prevalence of HPV in Ankang women in Shaanxi province is high. The common high-risk subtypes are HPV16, HPV58, HPV52, HPV53, HPV39 and HPV33, while the low-risk subtypes are HPV81 and HPV11. Different age groups of women with different subtypes of HPV infection. There were significant differences in mixed infection rates of HPV subtypes among women of different ages at high risk and high risk.