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目的 :研究生肌软膏对皮肤溃疡愈合的作用机理。 方法 :ccV大鼠 36只 ,制成溃疡模型 ,分为 2组 ,分别涂用生肌软膏和医用凡士林外用制剂 ,于给药的第 3、7、11d取溃疡处的全层组织 ,进行组织学观察。 结果 :生肌软膏组的溃疡面肉芽组织健康 ,毛细血管丰富 ,巨噬细胞较多 ,并有血管内皮生长因子 (VEGF)、增殖细胞核抗原 (PCNA)免疫组化检测 ,生肌软膏组的阳性细胞率明显高于凡士林组的阳性细胞率而支持。两组比较差别显著 (P <0 0 5 )。 结论 :中药外用制剂在治疗皮肤溃疡中有比较明显的优势 ,不仅可以促进溃疡的生长、愈合 ,还可以缩短愈合时间。
Objective: The mechanism of graduate student muscle ointment on skin ulcer healing. METHODS: Thirty-six ccV rats were made into ulcer models and divided into two groups. They were treated with Shengji ointment and medical Vaseline topical preparations. The full thickness tissues of ulcers were taken on the 3rd, 7th, and 11th days after administration for histological observation. . RESULTS: The granulation tissue of the ulcer surface of Shengji ointment group was healthy, there were abundant capillaries, there were many macrophages, and there were immunohistochemical examinations of vascular endothelial growth factor (VEGF) and proliferating cell nuclear antigen (PCNA). Positive results of Shengji ointment group. The cell rate was significantly higher than that of the Vaseline group. The difference between the two groups was significant (P < 0.05). Conclusion : External preparations of traditional Chinese medicine have obvious advantages in the treatment of skin ulcers, which can not only promote the growth and healing of ulcers, but also shorten the healing time.