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在。“两肾一环”肾性高血压大鼠观察到健侧肾脏CaM含量明显升高,与对照组及假手术组比较。分别为38.4±5.5;18.7±1.74和17.3±1.65ng/μgDNA(P<0.05)。实验组主动脉CaM含量也明显增加,与对照组及假手术组比较分别为0.65±0.09,0.31±0.11和0.32±0.07μg/mg蛋白(P<0.02)。实验组主动脉cAMP含量为7.30±1.18,明显高于空白对照组2.97±0.75(pmol/mg蛋白) (P<0.02)及假手术组1.58±0.49 pmol/mg(P<0.001)。而假手术组与对照组之间无明显差异。在心脏组织中各组间CaM含量无明显差异。经初步分析推测Ca及cAMP可能通过参与对血管平滑肌及肾素-血管紧张素-醛固酮系统的调节而对高血压的发病产生作用。
in. “Renal ring” renal hypertensive rats observed in healthy kidney CaM content was significantly increased, compared with the control group and sham operation group. 38.4 ± 5.5; 18.7 ± 1.74 and 17.3 ± 1.65 ng / μg DNA, respectively (P <0.05). The content of CaM in the aorta in the experimental group also increased significantly, which were 0.65 ± 0.09,0.31 ± 0.11 and 0.32 ± 0.07μg / mg protein (P <0.02) compared with the control group and the sham operation group respectively. The cAMP content of the aorta in the experimental group was 7.30 ± 1.18, significantly higher than that of the control group (2.97 ± 0.75 pmol / mg protein) and the sham group (1.58 ± 0.49 pmol / mg, P <0.001). There was no significant difference between the sham operation group and the control group. There was no significant difference in CaM content between groups in cardiac tissue. Preliminary analysis suggests that Ca and cAMP may play a role in the pathogenesis of hypertension by participating in the regulation of vascular smooth muscle and renin-angiotensin-aldosterone system.