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目的研究胸腔内置管引流加卡铂、白细胞介素(IL)-2胸腔内注射治疗恶性胸腔积液的疗效及副作用。方法将88例恶性胸腔积液患者随机分为治疗组48例和对照组40例,治疗组在常规化疗的基础上予胸腔内置入导管间断放净胸水后注入卡铂、IL-2进行治疗,对照组在常规化疗的基础上予胸腔置入导管行胸腔引流治疗。结果治疗组有效率83.3%,对照组有效率52.5%,两组疗效比较差异有统计学意义(P<0.05)。治疗组发生恶心、呕吐、胸痛、心悸、低热、白细胞和血小板减少等不良反应,经对症处理后恢复。无胸腔感染发生。结论胸腔内置管引流加卡铂、IL-2胸腔内注射治疗恶性胸腔积液的疗效确切,对缓解患者的临床症状、提高生活质量有一定意义。
Objective To study the curative effect and side effects of intrathoracic catheter drainage of carboplatin and interleukin (IL) -2 in the treatment of malignant pleural effusion. Methods Eighty-eight patients with malignant pleural effusion were randomly divided into treatment group (n = 48) and control group (n = 40). The treatment group was treated with carboplatin and interleukin-2 after discontinuation of the pleural effusion by intrathoracic catheterization based on routine chemotherapy. The control group was treated by thoracic drainage on the basis of conventional chemotherapy. Results The effective rate was 83.3% in the treatment group and 52.5% in the control group, with significant difference between the two groups (P <0.05). Treatment group nausea, vomiting, chest pain, palpitations, fever, leukopenia and thrombocytopenia and other adverse reactions, symptomatic treatment after recovery. No thoracic infection occurs. Conclusion Intrathoracic tube drainage plus carboplatin, IL-2 intrapleural injection of malignant pleural effusion curative effect is exact, to alleviate the clinical symptoms and improve the quality of life of some significance.