论文部分内容阅读
目的 探讨nm2 3-H1和CD44V6在肺鳞癌组织中表达及预后意义。方法 应用免疫组化S -P法 ,对 96例肺鳞癌组织进行nm2 3-H1和CD44V6检测并对其中 6 6位患者进行了 5年随访。结果 96例肺鳞癌的nm2 3-H1、CD44V6阳性表达率分别为 46 .9%和 42 .7%。nm2 3-H1蛋白表达同病理分期和淋巴结转移呈负相关 ,其预后佳。CD44V6表达与肺鳞癌大小、病理分期和淋巴结转移呈正相关 ,其预后差。结论 nm2 3-H1和CD44V6可作为检测肺鳞癌临床特征及预后参考指标
Objective To investigate the expression and prognostic significance of nm23-H1 and CD44V6 in lung squamous cell carcinoma. Methods Immunohistochemical S-P method was used to detect nm23-H1 and CD44V6 in 96 cases of lung squamous cell carcinoma and 6 of them were followed up for 5 years. Results The positive rates of nm23-H1 and CD44V6 in 96 cases of lung squamous cell carcinoma were 46.9% and 42.7%, respectively. The expression of nm2 3-H1 protein was negatively correlated with pathological stage and lymph node metastasis, and its prognosis was good. The expression of CD44V6 was positively correlated with the size, pathological stage, and lymph node metastasis of lung squamous cell carcinoma, and its prognosis was poor. Conclusion nm2 3-H1 and CD44V6 can be used as a reference for the detection of clinical features and prognosis of squamous cell carcinoma of the lung