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观察了11例慢性阻塞性肺疾病（COPD）患者吸入 40μl/L一氧化氮（NO）前后血流动力学、动脉和混合静脉血气、肺内气体交换、氧运输功能及高铁血红蛋白（MetHb）的变化。结果见吸入 NO 2、8、15 min时,肺动脉平均压（mPAP）分别下降了 21.97％、23.93％和 23.28％,肺血管阻力（PVR）分别下降了33.35％、28.07％和31.09％（均为P<0.01）;停止吸入NO 2 min时,mPAP和PVR恢复至吸入前水平。吸入NO对其余指标无明显影响。提示吸入NO选择性降低COPD患者肺动脉压,且具有速效、不影响血气和氧运输功能等特点。
Eleven patients with chronic obstructive pulmonary disease (COPD) were studied for hemodynamics, arterial and venous blood gas, intrapulmonary gas exchange, oxygen transport and methemoglobin (MetHb) before and after inhaling 40 μL / L nitric oxide Variety. Results The mean pulmonary artery pressure (mPAP) decreased by 21.97%, 23.93% and 23.28%, respectively, while the pulmonary vascular resistance (PVR) decreased by 33.35%, 28.07% and 31.09% P <0.01). When inhaled NO 2 min, mPAP and PVR returned to pre-inhalation levels. Inhalation of NO had no significant effect on the remaining indicators. Prompt NO inhalation selectively reduce pulmonary arterial pressure in patients with COPD, and with immediate effect, does not affect blood gas and oxygen transport functions and so on.