论文部分内容阅读
目的:探讨药物代谢酶CYP2C19基因多态性与维吾尔族冠心病合并糖尿病患者的血糖相关性,并研究年龄对其多态性的影响。方法:将299例住院的维吾尔族患者分为对照组(非冠心病、糖尿病患者)、单纯冠心病组及冠心病合并糖尿病组,其中男219例,女80例;检测入选患者CYP2C19基因型;测定3组指标对所得结果进行t检验、单因素方差分析等,并比较不同年龄组(<60岁和≥60岁)基因多态性差异。结果:该研究一共检测到CYP2C19的6种不同基因型、3种代谢型,快代谢型EM(CYP2C19*1/*1)60.5%,中代谢型IM(CYP2C19*1/*2,CYP2C19*1/*3)33.1%,慢代谢型PM(CYP2C19*2/*2,CYP2C19*2/*3,CYP2C19*3/*3)6.4%。3组年龄、血小板计数、空腹葡萄糖、糖化血红蛋白比较差异有统计学意义(均P<0.05)。Logistic回归分析显示,在调整了年龄、性别、高血压等传统危险因素之后,总胆固醇与低密度脂蛋白是CYP2C19基因多态性的独立预测因子(总胆固醇OR=11.892,P<0.05;低密度脂蛋白OR=7.415,P<0.05)。糖尿病病史亦是危险因素之一(OR=1.147,95%CI:0.651~2.023)。结论:冠心病合并糖尿病与CYP2C19基因多态性具有相关性。
Objective: To investigate the relationship between CYP2C19 gene polymorphism and diabetes mellitus in Uygur patients with coronary heart disease and to investigate the influence of age on its polymorphism. Methods: 299 Uyghur hospitalized patients were divided into control group (non-coronary heart disease, diabetes), simple coronary heart disease group and coronary heart disease with diabetes group, including 219 males and 80 females; CYP2C19 genotypes were detected in selected patients; Three groups of indicators were determined by t test, one-way analysis of variance and so on, and to compare different age groups (<60 years and ≥ 60 years) genetic polymorphism. RESULTS: Six genotypes of CYP2C19, three metabolites, 60.5% of CYP2C19 * 1 / * 1, CYP2C19 * 1 / * 2 and CYP2C19 * 1 / * 3), slow-metabolizing PM (CYP2C19 * 2 / * 2, CYP2C19 * 2 / * 3, CYP2C19 * 3 / * 3) 6.4%. Three groups of age, platelet count, fasting glucose, glycosylated hemoglobin difference was statistically significant (P <0.05). Logistic regression analysis showed that total cholesterol and LDL were independent predictors of CYP2C19 gene polymorphism (total cholesterol OR = 11.892, P <0.05) after adjusting for traditional risk factors such as age, sex and hypertension. Low-density Lipoprotein OR = 7.415, P <0.05). Diabetes history is also a risk factor (OR = 1.147, 95% CI: 0.651 to 2.023). Conclusion: Coronary heart disease complicated with diabetes has a correlation with CYP2C19 gene polymorphism.