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目的 研究人用狂犬病纯化疫苗的安全性和保护性。方法 采用狂犬病疫苗暴露后免疫程序接种受试人群 ,I期临床接种 2 0人 ,II、III期临床接种 30 4人 ,观察注射后反应 ,采用小鼠脑内中和试验法测定其中 6 2人中和抗体水平。结果 全部受试者有 13.2 7%出现轻度副反应 ,无中强度副反应 ,中和抗体阳转率为 10 0 % ,中和抗体GMT为 11.89IU/ml。结论 该疫苗对人体安全且具有较好的免疫原性
Objective To study the safety and protection of rabies vaccine for human use. Methods The rabies vaccination program was used to inoculate rabies vaccine in population. Phase I clinical inoculation was performed in 20 patients. Phase II and III clinical inoculation was performed in 30 4 patients. The response after injection was observed. Sixty-two Neutralize antibody levels. Results All subjects had mild side effects with 13.2%, no moderate side effects, neutralization antibody positive conversion rate of 10% and neutralizing antibody GMT of 11.89IU / ml. Conclusion The vaccine is safe to humans and has good immunogenicity