论文部分内容阅读
本组测定29例病人伤后48h内及1周时的血清铜、铁值,13例病人伤后48h内的血清锰值。结果表明,伤后48h内,血清铜升高显著(P<0.01),铁下降明显(P<0.01),锰变化不大(P>0.05)。在排除了手术因素后,结果仍与上述结果基本相同。伤后1周,血清铜仍保持高水平(P<0.01),血清铁恢复正常。作者认为,颅脑损伤急性期,血清铜的升高和血清铁的降低符合“白细胞内源递质”学说;同时,脑组织及含铜酶的破坏,使铜释放入血,也可能是血清铜上升的另一个重要因素,尤其是在伤后48h内。血清铜的升高可能在增强机体防御、阻止脑水肿恶化和组织修复方面起重要的作用。血清铁的下降究竟对机体有利或是有害尚不清楚。
This group measured 29 patients within 48h after injury and 1 week serum copper, iron value, 13 patients within 48h after injury serum manganese value. The results showed that within 48 hours after injury, serum copper increased significantly (P <0.01), iron decreased significantly (P <0.01), manganese did not change much (P> 0.05). After excluding the surgical factors, the results are still basically the same as the above results. One week after injury, serum copper remained high (P <0.01) and serum iron returned to normal. The author believes that acute brain injury, increased serum copper and serum iron in line with “leukocyte endogenous neurotransmitter ” theory; the same time, the destruction of brain tissue and copper-containing enzymes, the release of copper into the blood may also Is another important factor in the rise of serum copper, especially within 48 hours after injury. Elevated serum copper may play an important role in enhancing body defense, deterring the deterioration of brain edema and tissue repair. Whether serum iron decline is beneficial or harmful to the body is unclear.