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测定斯巴沙星对１３６株革兰氏阳性菌抗菌活性，并与其它４种抗菌药物比较。结果表明斯巴沙星对葡萄球茵、肠球菌、肺炎球菌、草绿色及溶血性链球菌的ＭＩＣ９０为０．０６－８μｇ／ｍｌ，远较苯唑西标及头孢唑啉低，其抗菌活性为氧氟沙星的２—１６倍，环丙沙星的１—８倍。对甲氧西林敏感与耐药的葡萄球菌，氟喹诺酮类具有相同抗菌活性，ＭＩＣ９０均为２—１６μｇ／ｍｌ。斯巴沙星为临床治疗革兰氏阳菌感染的有效药物。
The antibacterial activity of Spartacin against 136 Gram-positive bacteria was determined and compared with the other 4 antibacterials. The results showed that the MIC90 of sparfloxacin against Staphylococcus aureus, Enterococcus, pneumococcus, grass green and hemolytic streptococcus was 0.06-8μg / ml, which was much lower than that of oxacillin and cefazolin. The antibacterial activity 2 to 16 times of ofloxacin and 1 to 8 times of ciprofloxacin. Methicillin-resistant and resistant Staphylococcus aureus, fluoroquinolones have the same antibacterial activity, MIC90 are 2-16μg / ml. Spartaine is an effective drug for the clinical treatment of Gram-positive bacteria.