论文部分内容阅读
84例HCV感染儿中,63.1％有输血制品史;5例≤6月龄婴儿(1例有输血史)母亲HCV标志阳性;1例在其父患输血后丙肝21月后筛查发现血清HCV RNA和抗HCV阳性。除外原有其他肝病者,62例患儿临床上以急性无黄疸型(25.8％)、亚临床型(20.9％)和无症状感染(25.8％)多见。仅5例为急性黄疸型(8.1％),慢性型占19.4％.并见HAV、HBV和HCV三重感染2例,HCV与HAV和HAV二重感染各6例和16例;与CMV混合感染3例。慢性和无症状HCV感染儿中混同HBV感染最多见(11/16,68.8％),1例肝活检证实有肝硬变。血清HCV标志检测表明,HCV RNA在免疫发育不完善的婴儿、免疫抑制者及感染早期特异性抗体未能检出时更具诊断价值。9例接受α-干扰素辅以病毒唑治疗,近期病毒清理率达55.6％。
Of the 84 HCV-infected children, 63.1% had a history of blood transfusions; 5 of 6 infants <6 months of age (one having a history of transfusions) had a positive HCV marker; one had a serum HCV RNA and anti-HCV positive. Except for those with other liver diseases, 62 cases were clinically acute jaundice (25.8%), subclinical (20.9%) and asymptomatic infection (25.8%). Only 5 cases were acute jaundice (8.1%) and chronic type accounted for 19.4% .There were 2 cases of HAV, HBV and HCV triple infection, 6 cases of HCV and HAV and 6 cases of HAV and 16 cases of mixed infection with CMV example. Among the children with chronic and asymptomatic HCV infection, the most common infection was HBV infection (11/16, 68.8%). One liver biopsy confirmed liver cirrhosis. Serum HCV markers showed that HCV RNA is more valuable in the diagnosis of infantile immunocompromised infants, immunosuppressed individuals and early antibody-specific antibodies. Nine patients received a-interferon plus ribavirin treatment, the recent virus clearance rate of 55.6%.