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目的观察促性腺激素释放激素激动剂(GnRH-α)联合左炔诺孕酮宫内缓释系统(LNG-IUS)治疗增大子宫的子宫腺肌病临床疗效。方法 11例宫腔深度>9cm子宫腺肌病患者,于月经周期第1~5天肌肉注射GnRH-α,每4周1次,每次注射前B超测量子宫体积及宫腔深度,至宫腔深度≤9cm时,放置LNG-IUS。放置后3、6、12个月各复诊1次,观察疼痛评分(VAS)、月经量评分(PBAC)、子宫体积、宫腔深度变化。结果放置LNG-IUS后6、12个月,患者VAS、PBAC、子宫体积和宫腔深度与联合治疗前比较差异有统计学意义(P<0.05)。结论 GnRH-α联合LNG-IUS治疗增大子宫的子宫腺肌病的疗效显著。
Objective To observe the clinical efficacy of GnRH-α combined with levonorgestrel-releasing intrauterine system (LNG-IUS) in the treatment of uterine adenomyosis. Methods 11 cases of uterine adenomyosis with uterine cavity depth> 9cm were intramuscularly injected with GnRH-α on the first to fifth days of the menstrual cycle and once every four weeks. The uterine volume and uterine cavity depth were measured before each injection. When the cavity depth is less than 9cm, place LNG-IUS. The patients were referred at 3, 6, and 12 months after operation, and the pain scores (VAS), menstrual flow score (PBAC), uterine volume and uterine cavity depth were observed. Results The VAS, PBAC, uterine volume and uterine cavity depth at 6 and 12 months after LNG-IUS implantation were significantly different from those before combined treatment (P <0.05). Conclusion GnRH-α combined with LNG-IUS treatment of uterine adenomyosis significant effect.