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目的：探讨乳腺癌患者组织中的血管内皮生长因子（vascular endothelial growth factor, VEGF）表达的临床意义。方法采用组织芯片技术和免疫组织化学的方法检测60例乳腺癌患者、31例正常乳腺组织中VEGF的表达，分析其与临床病理特征之间的关系，并进行了比较性分析。结果正常乳腺组织、乳腺癌组织的VEGF阳性表达差异具有统计学意义（P＜0.05），VEGF阳性表达率与患者淋巴结转移情况差异亦具有统计学意义（P＜0.05），VEGF阳性表达率与患者年龄，肿块大小情况差异无统计学意义（P均＞0.05），单因素和多因素Logistic回归分析显示：VEGF表达是乳腺癌的危险因素， VEGF阳性患者乳腺癌风险是阴性者的4.84倍（95%CI：1.42～17.2）。结论在乳腺癌患者中VEGF呈高表达，提示VEGF在乳腺癌发生和发展过程中发挥着重要的作用，VEGF亦可作为预后评估的指标。“,”Objective To explore the clinical significance on expression of VEGF in breast cancer tissue. MethodsImmunohistochemical SP staining method and tissue chip were adopted to research the expression of VEGF in 60 patients with breast cancer and 31 cases normal breast tissue as control. Multivariate logistic regression and spearman correlation were performed to analyze the relationship between these cases and their clinicopathologic characteristics and compared analysis was done.ResultsThe difference of positive rate of VEGF was signiifcant between breast cancer tissue and normal breast tissue (P<0.05). The positive expression rate of VEGF was related to lymphnode metastasis (P0.05). Univariate and multivariate logistic regression showed that expression of VEGF wasa risk factor of breast cancer. The risk of breast cancer in VEGF positive patients was 4.84 times that of VEGF negative patients (95%CI: 1.42~17.2).Conclusion There was high positive expression of VEGF in breast cancer patients, which suggested that these factors were concerned with the development of breast cancer so as to be contributed to prognostic judgment.