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本文报告胰岛素A键Cbz(S-Bz)Cys—Ala·Gly·Val·(S-Bz)Cys·O-Bz(A_7-A_(11))五肽和Cbz(S-Bz)Cys·(S-Bz)Cys·Ala-Gly-Val·(S-Bz)Cys-OEt(A_6-A_(11))六肽的合成。五肽是用活化酯方法,由Cbz(S-Bz)Cys-ONP与H·Ala-Gly·Val·(S-Bz)Cys·OBz(A_3-A_(11))合成。将纯浄的Cbz(S-Bz)Cys-(S-Bz)Cys-OH和旋光纯的H·Ala·Gly·Val(S-Bz)Cys·OEt四肽,经混合酸酐和碳二亚胺两种方法接肽,获得熔点和比旋度完全一致的六肽。该六肽Cbz(S-Bz)Cys-(S-Bz)Cys·Ala·Gly·Val·(S-Bz)Cys·OEt(A_6-A_(11))应为光学纯的化合物。
This paper reports the pentapeptide and Cbz (S-Bz) Cys · (S-Bz) Cys- Ala · Gly · Val · (S-Bz) Cys · O-Bz -Bz) Cys · Ala-Gly-Val · (S-Bz) Cys-OEt (A_6-A_ (11)) hexapeptide. The pentapeptide was synthesized from Cbz (S-Bz) Cys-ONP and H · Ala-Gly · Val · (S-Bz) Cys · OBz (A_3-A_ (11)) using an activated ester method. The pure Cbz (S-Bz) Cys- (S-Bz) Cys-OH and the optically pure H Ala · Gly · Val (S-Bz) Cys · OEt tetrapeptide were treated with mixed anhydride and carbodiimide The two methods are followed by peptide to obtain the hexapeptide which has the same melting point and specific rotation. The hexapeptide Cbz (S-Bz) Cys- (S-Bz) Cys Ala Ala Val Val (S-Bz) Cys OEt (A_6-A_ (11)) should be an optically pure compound.