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2例阵发性室速和7例心绞痛患者在进行心脏手术前,用Am(乙胺碘呋酮)口服治疗(每日200～400毫克)至少九个月。根据药物治疗前和进行手术之前当时所记录的心电图Ⅱ导联测量QT间期。手术开始时采集血浆和心肌标本,利用高性能液体层析法测量Cp(血浆浓度)和Cm(心肌浓度)。Am可致校正QT间期显着延长。在Cp和Cm之间存在着良好关联,而且两者均与校正QT间期的增长百分率有关。Cp和Cm与给药剂量(按每公斤每日的毫克计)也高度相关,校正QT间期的增长百分率也与给药剂量相关良好。因此校正QT间期延长的程度可在临床上用来估量Am的Cm。
Two patients with paroxysmal VT and seven patients with angina were treated orally with Am (amiodarone) (200-400 mg daily) for at least nine months prior to cardiac surgery. The QT interval was measured according to the electrocardiogram II lead recorded prior to the drug treatment and prior to the operation. Plasma and myocardial samples were collected at the start of surgery and Cp (plasma concentration) and Cm (myocardial concentration) were measured by high performance liquid chromatography. Am can be corrected QT interval significantly longer. There is a good correlation between Cp and Cm, and both are related to the percentage increase in QT interval correction. Cp and Cm were also highly correlated with dosing (in milligrams per kilogram per day), and the percentage increase in corrected QT interval was also well correlated with the dose administered. Therefore, the extent of correction of QT interval can be clinically used to measure Am’s Cm.