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目的探讨影响慢性乙型重型肝炎患者预后的危险因素。方法收集浙江大学医学院附属第一医院345例慢性乙型重型肝炎患者临床资料,根据治疗结果分为好转组和恶化组,回顾性分析患者9项临床资料与预后间的相关性。结果患者年龄、重叠其他病毒感染、有无合并肝硬化以及是否抗病毒治疗2组间差异有统计学意义(P<0.05),而患者性别、嗜烟酒、并发糖尿病和高血压等因素在2组间差异无统计学意义(P>0.05)。结论年龄较大,重叠其他病毒感染,有肝硬化基础及未经抗毒治疗的慢性乙型重型肝炎患者预后较差。
Objective To investigate the risk factors affecting the prognosis of patients with chronic severe hepatitis B Methods The clinical data of 345 patients with chronic severe hepatitis B from the First Affiliated Hospital of Zhejiang University were collected. According to the results of treatment, the patients were divided into improvement group and exacerbation group. The correlation between 9 clinical data and prognosis was retrospectively analyzed. Results There was significant difference between the two groups (P <0.05). There was significant difference between the two groups in the age of patients, overlapping other virus infection, cirrhosis with or without antiviral therapy (P <0.05), but gender, alcohol and tobacco consumption, There was no significant difference between groups (P> 0.05). Conclusions Older patients who overlap with other viral infections, with the basis of cirrhosis and chronic hepatitis B without anti-drug therapy have a poor prognosis.