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Combined hepatocellular and cholangiocarcinoma(CHC),which is characterized by hepatocellular and biliary epithelial differentiation within the same tumor,is a unique type of primary hepatic carcinoma that is distinct from hepatocellular carcinoma(HCC)and intrahepatic cholangiocarcinoma(ICC).An accurate method to identify the origin of CHC is to determine whether the tumor components(i.e.,HCC and ICC)are from a single clonal origin or multiple clonal origins.The cover art shows the
Combined hepatocellular and cholangiocarcinoma (CHC), which is characterized by hepatocellular and biliary epithelial differentiation within the same tumor, is a unique type of primary hepatic carcinoma that is distinct from hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). An accurate method to identify the origin of CHC is to determine whether the tumor components (ie, HCC and ICC) are from a single clonal origin or multiple clonal origins. cover art shows the