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近年来冠心病病理生理的性别差异得到广泛研究,取得不少进展。大量的实验资料(1—5)表明:心脏是雌、雄激素的靶器官,一些大血管壁上均存在着雌、雄激素受体;性激素是心血管系统的一种重要调节激素,性激素缺乏使大鼠心脏肌球蛋白C_(?)~(2+)—AT P酶活性降低,肌球蛋白优势型同功酶由活性较高的V_1转为活性低的V_3,同时心功能降低,用相应性激素替代则可矫正之。但心肌梗塞(MI)前后血浆性激素含量的变化、对正常及实验性MI大鼠心功能的影响,尚罕见专题报道。为此,本实验通过摘除睾丸,摘除睾丸后用丙酸睾丸Ⅰ素
In recent years, the gender differences in the pathophysiology of coronary heart disease have been extensively studied and many progresses have been made. A large number of experimental data (1–5) indicate that the heart is the target organ of both female and male hormones, and that there are female and androgen receptors on the walls of some large blood vessels. Sex hormones are an important regulatory hormone in the cardiovascular system and lack of sex hormones. The activity of cardiac myosin C_(2+)-ATP enzyme was decreased in rats, and the predominant isoenzyme of myosin was changed from V_1 with higher activity to V_3 with low activity, and cardiac function was decreased. Corresponding hormone replacement can be corrected. However, the changes of plasma sex hormone levels before and after myocardial infarction (MI) and the effects on the heart function of normal and experimental MI rats are still rare. For this purpose, this test was performed by removing the testis and removing the testis with testosterone propionate.