Using recent data of geoscience transaction in Northeast China, the author analyses and studies the crust-upper mantle structure feature of the North Tanlu fault zone. The result shows the crust-mantle structure are obvious difference at both sides of the North Tanlu fault zone. The fault activity and segmentation are closely related with abruptly change zone of the crust-upper mantle structure. There is a clear mirror image relationship between the big geomorphic shape and asthenosphere undulate, the former restricts tectonic stability and tectonic style of dif- ferent crustal units. The significantly strengthening seismicity of north set and south set in the North Tanlu fault zone just correspond to the low-velocity and high conductivity layer of crust-upper mantle. In the North Tanlu fault zone, the main controlling structure of the mid-strong seismic generally consists of the active fault sectors, whose crust-mantle structure is more complicated in rigidity massif. Using recent data of geoscience transaction in Northeast China, the author analyzes and studies the crust-upper mantle structure feature of the North Tanlu fault zone. The result shows the crust-mantle structure are obvious difference at both sides of the North Tanlu fault zone. The fault activity and segmentation are closely related with abruptly change zone of the crust-upper mantle structure. There is a clear mirror image relationship between the big geomorphic shape and asthenosphere undulate, the former restrictions tectonic stability and tectonic style of dif- ferent crustal units . The significant strengthening seismicity of north set and south set in the North Tanlu fault zone just correspond to the low-velocity and high conductivity layer of crust-upper mantle. In the North Tanlu fault zone, the main controlling structure of the mid-strong seismic generally consists of the active fault sections, whose crust-mantle structure is more complicated in rigidity massif.