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脑与免疫系统之间进行信息传递是通过脑中细胞因子表达和免疫系统中神经肽表达而进行的。促肾上腺皮质激素（ＡＣＴＨ）和促阿片黑素细胞皮质素原（ＰＯＭＣ）基因的肽产物—阿片β内啡肽是首次报道存在于淋巴细胞中的神经肽。虽然关于ＰＯＭＣ在免疫组织中表达的报道很多
The transmission of information between the brain and the immune system is through the expression of cytokines in the brain and neuropeptide expression in the immune system. Adiponectin β-endorphin, a peptide product of adrenocorticotropic hormone (ACTH) and pro-opiomelanocortin (POMC) genes, is the first reported neuropeptide in lymphocytes. Although there are many reports on the expression of POMC in the immune tissues