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胞生兄妹同时患同一细胞类型白血病的报告极少,现将我院收治的2例报告如下。例1 男,12岁。诉头昏、全身乏力、面色逐渐苍白20余天,近1周来双下肢皮肤出现散在性出血点,时有不规则发热,1986年2月24日来院就诊。查体:体温37.6℃,神志清,精神萎靡,呈重度贫血貌。两侧颈淋巴结蚕豆大小,活动、无压痛,胸骨有压痛。心率114次/分,心尖部Ⅲ级收缩期杂音,腹部膨隆。肝肋下1.5cm,脾肋下未扪及,下肢有少数散在性出血点。患病前无特殊服药及接触放射线病史,但其对门邻居有患急性粒细胞白血病患者。血红蛋白<40g/L,红细胞1.25×10~(12)/L,白细胞7.6×10~9/L,中性48%,淋巴45%,幼稚细胞3%,血小板计数74×10~9/L。骨髓象:增生极度活跃,原粒83%,早幼粒14%,过氧化酶染色阳性,全片未见巨核细胞,血小板少见。诊断:急性粒细胞白血病。经HOAP方案化疗。多次输血,服中药等治疗,病情未能缓解,于1986年4月1日死亡。
Cytomegalic at the same time suffering from the same cell type leukemia is rarely reported in our hospital 2 cases are reported below. Example 1 male, 12 years old. V. Dizziness, malaise, looking pale gradually more than 20 days, nearly 1 week to double extremity skin scattered bleeding, when irregular fever, February 24, 1986 to the hospital. Physical examination: body temperature 37.6 ℃, conscious mind, apathetic, was severe anemia appearance. Broad beans on both sides of the neck lymph node size, activity, no tenderness, tenderness in the sternum. Heart rate 114 beats / min, apical grade Ⅲ systolic murmur, abdominal bulging. Liver ribs 1.5cm, spleen and ribs are not palpable, a small number of scattered lower extremity bleeding. Before the illness without special medication and exposure to radiation history, but its neighbors with patients suffering from acute myeloid leukemia. Hemoglobin <40g / L, erythrocytes 1.25 × 10-12 / L, white blood cells 7.6 × 10 ~ 9 / L, neutral 48%, lymphatic 45%, naive cells 3%, platelet count 74 × 10 ~ 9 / Bone marrow: Hyperplasia extremely active, 83% of the original particles, promyelocytic 14%, positive staining for peroxidase, the whole piece no megakaryocytes, rare platelets. Diagnosis: acute myeloid leukemia. The HOAP regimen chemotherapy. Many transfusions, taking traditional Chinese medicine and other treatment, the disease failed to alleviate, died in April 1, 1986.