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以对甲基苯乙酮为原料 ,经缩合、环合反应合成选择性 COX- 2抑制剂 Celecoxib,总收率 37.7%。
Using p-methylacetophenone as raw material, Celecoxib, a selective COX-2 inhibitor, was synthesized by condensation and cyclization. The total yield was 37.7%.