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健康成年金黄仓鼠腹腔内接种ＰＶＨ－１（５×１０６ｐｆｕ），ＦＣＭ动态检测肝细胞ＤＮＡ周期动力学变化，结果显示：ＰＶＨ－１接种后处于Ｇ０＋Ｇ１期的肝细胞与对照组动物相比无显著差异。Ｓ期肝细胞在第３天显著高于对照组动物（Ｐ＜０．０５），且在第７天时仍呈上升趋势，第１４天到３０天趋于正常水平。Ｇ２＋Ｍ期肝细胞在ＰＶＨ－１接种后第３０天升高（Ｐ＜０．０５）。结果提示，动物在ＰＶＨ－１接种后第３到第７天是病毒在肝细胞中的复制高峰，并阻滞仓鼠处于Ｓ期肝细胞分裂进入Ｇ２＋Ｍ期，但是这种阻滞作用较短暂、并可逆，在ＰＶＨ－１接种后１４～３０天自然消失。
The healthy adult golden hamster was inoculated intraperitoneally with PVH-1 (5 × 106pfu) and the FCM was used to detect the dynamic changes of DNA in the hepatocytes. The results showed that there was no significant difference between the control group and the hepatocytes in the G0 + G1 phase after PVH-1 inoculation . S phase hepatocytes were significantly higher than that of the control group on the third day (P <0.05), and still showed an upward trend on the seventh day, and tended to be normal on the 14th to 30th day. G2 + M-phase hepatocytes increased 30 days after PVH-1 inoculation (P <0.05). The results suggest that the animals replicated in the hepatocytes at day 3 to day 7 after PVH-1 inoculation and blocked the hamster in stage S hepatocyte division into G2 + M phase, but this block was transient and Reversible, disappear naturally 14 to 30 days after PVH-1 inoculation.