论文部分内容阅读
目的探讨新诊断2型糖尿病(DM)患者亚临床动脉粥样硬化发生率及相关危险因素。方法采用无创性高分辨超声血管成像技术筛查2002年6月至10月在卫生部北京医院内分泌科确诊的414例病程≤1年的2型糖尿病患者颈动脉、髂总动脉和股动脉内中膜厚度(IMT)及动脉粥样硬化斑块。分析有无亚临床动脉粥样硬化的两组患者年龄、性别、吸烟、体重指数(BMI)、腰臀比、收缩压、舒张压、空腹血糖(FBG)、餐后2h血糖(PBG)、糖化血红蛋白(HbA1c)、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)等方面的差异。采用Logistic回归分析各危险因素与亚临床动脉粥样硬化的关系。结果(1)414例患者中,亚临床动脉粥样硬化者165例,占39.8%。(2)亚临床动脉粥样硬化组与无动脉粥样硬化组比较,年龄、收缩压、FBG、PBG、HbA1c、HDL-C差异均有统计学意义。(3)logistic回归分析显示,男性、吸烟、年龄增加、收缩压及PBG升高是亚临床动脉粥样硬化发生的独立危险因素。结论新诊断2型糖尿病患者部分存在亚临床动脉粥样硬化,与多种危险因素有关,须及早控制各种危险因素以防止大血管病变的发生发展。
Objective To investigate the incidence of subclinical atherosclerosis and related risk factors in newly diagnosed type 2 diabetic patients. Methods Noninvasive high resolution ultrasound angiography was used to screen 414 carotid, common iliac and femoral arteries in type 2 diabetic patients with disease duration ≤ 1 year diagnosed in Department of Endocrinology, Beijing Hospital of Ministry of Health, China from June to October in 2002. Film thickness (IMT) and atherosclerotic plaques. Age, sex, smoking, body mass index (BMI), waist-hip ratio, systolic blood pressure, diastolic blood pressure, fasting blood glucose (FBG), postprandial 2h blood glucose (PBG) HbA1c, TC, TG, LDL-C, HDL-C and so on. Logistic regression analysis was used to analyze the association of risk factors with subclinical atherosclerosis. Results (1) Of the 414 patients, 165 were subclinical atherosclerosis, accounting for 39.8%. (2) There were significant differences in age, systolic blood pressure, FBG, PBG, HbA1c and HDL-C between subclinical atherosclerosis group and no atherosclerosis group. (3) Logistic regression analysis showed that men, smoking, age, systolic blood pressure and elevated PBG were independent risk factors of subclinical atherosclerosis. Conclusion There are subclinical atherosclerosis in newly diagnosed type 2 diabetic patients, which are related to many risk factors. Various risk factors must be controlled early to prevent the occurrence and development of macrovascular disease.