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目的:对比雷帕霉素药物洗脱支架(Cypher Select)、紫杉醇洗脱支架(Yinyi)和可降解涂层雷帕霉素药物洗脱支架(Excel)介入治疗,对不稳定型心绞痛(UAP)患者血清C反应蛋白(CRP)和白细胞介素-6(IL-6)的影响。方法:连续入选104例单支病变并接受介入治疗的UAP患者,依照置入支架种类分为Cypher组(33例)、Yinyi组(28例)和Excel组(43例)。于术前、术后48h、7d和30d时抽血,测定血清CRP和IL-6。结果:3组基本临床资料、冠状动脉介入治疗情况无明显差异。术后48h3组血清CRP和IL-6均较术前明显升高(P<0.01)。3组CRP和IL-6术后7d较术后48h下降,30d时降至显著低于术前水平。3组间比较,冠状动脉介入治疗术前、术后48h、7d和30d时,CRP和IL-6水平均无明显差异。结论:3种药物洗脱支架置入均可引起短期内炎症因子水平升高,但三者间比较对炎症因子水平的影响未见明显差异。
OBJECTIVE: To compare the effects of Cypher Select, Yinyi and degradable rapamycin-eluting stents (Excel) on unstable angina pectoris (UAP) The effects of serum C-reactive protein (CRP) and interleukin-6 (IL-6) in patients. Methods: One hundred and forty-four UAP patients were enrolled in this study. Cypher group (n = 33), Yinyi group (n = 28) and Excel group (n = 43) were enrolled in this study. Blood was drawn before operation, at 48h, 7d and 30d after operation, and serum CRP and IL-6 levels were measured. Results: The basic clinical data of 3 groups showed no significant difference in the interventional treatment of coronary artery. Serum CRP and IL-6 in postoperative 48h3 group were significantly higher than those before operation (P <0.01). The levels of CRP and IL-6 in 3 groups decreased from 48h after operation to 7d after operation, and dropped significantly to the preoperative level at 30d. There were no significant differences in CRP and IL-6 levels between the three groups before and after PCI at 48h, 7d and 30d after coronary intervention. CONCLUSION: All the three drug-eluting stents can cause the inflammatory cytokines to rise within a short period of time. However, there is no significant difference between the three groups on the level of inflammatory cytokines.