论文部分内容阅读
目的探讨原发性高血压并脑出血家族遗传因素与心血管病危险因素个体聚集性的关系。方法采用遗传流行病学方法,分析研究家系中直系、旁系心血管病危险因素的个体聚集性。结果超重、高甘油三酯、高总胆固醇、低高密度脂蛋白、高尿酸血症、高血糖及高肌酐血症等7种心血管病危险因素中至少2个危险因素的年龄标化率,直系高于旁系,将高血压病患者剔除后这种规律依然存在。结论遗传因素可能对心血管病危险因素聚集起重要作用。
Objective To investigate the relationship between the hereditary factors of hypertension and cerebral hemorrhage and the individual aggregation of risk factors of cardiovascular disease. Methods The methods of genetic epidemiology were used to analyze the individual aggregation of the risk factors of orthosteric and collateral cardiovascular diseases in pedigrees. Results The age-standardized rate of at least 2 risk factors of 7 cardiovascular diseases including overweight, high triglyceride, high total cholesterol, low-density lipoprotein, hyperuricemia, hyperglycemia and hyperkydronemia, Directly higher than the parallels, the high blood pressure patients removed after this rule still exists. Conclusion Genetic factors may play an important role in the aggregation of cardiovascular risk factors.