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２４只新西兰兔，随机分为４组。右膝髌骨手术方法造成髌骨倾斜状态为实验侧，左膝实施假手术为对照侧，定期处死动物后进行软骨组织病理观察以及纤维连接蛋白的免疫组化（ＬＡＢ法）定位。结果：术后１２周实验膝髌内侧面软骨中层、深层细胞与细胞外基质变性并形成裂隙，与髌软骨软化的病理改变相似。上述软骨变性部位软骨细胞浆内以及细胞外软骨基质纤维连接蛋白明显增多，特别是软骨细胞周缘与基质交界处增多最显著。表明纤维连接蛋白增多部位与髌软骨软化部位一致，纤维连接蛋白增多与髌软骨软化的发生密切相关。
Twenty-four New Zealand rabbits were randomly divided into four groups. Right knee patella surgery caused the patellar tilt state on the experimental side, the left knee to perform sham operation as the control side, the animals were sacrificed on a regular basis after cartilage histopathology and fibronectin immunohistochemical (LAB method) positioning. Results: Twelve weeks postoperatively, the medial and deep layers of cartilage in the knee patella were degenerated and formed a fissure, which was similar to the pathological changes of patella cartilage. The above cartilage degeneration site chondrocyte plasma and extracellular cartilage matrix fibronectin increased significantly, especially at the junction of chondrocyte peripheral and stromal increased the most significant. That part of increased fibronectin and patella cartilage softening consistent with increased fibronectin and patella cartilage softening is closely related.