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表观遗传修饰的主要分子机制有DNA甲基化和组蛋白修饰。异常的表观遗传修饰会导致肿瘤发生。因此,对表观遗传的调节机制及其可逆性的研究将鉴别出一些新的靶点,为肿瘤的分子靶向治疗提供新的方向。
The main molecular mechanisms of epigenetic modification are DNA methylation and histone modification. Aberrant epigenetic modifications lead to tumorigenesis. Therefore, the research on the mechanism of epigenetic regulation and its reversibility will identify some new targets and provide a new direction for molecular targeted therapy of tumors.