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作者用红外光谱法,薄层层析法研究了用 PEG-6000制得呋喃妥因、3-乙基-5-苯海因(ethotoin)、香豆素的固体分散物和用 PVP-25000制得的共沉淀物及物理混合物的溶出速率和药物-载体间的相互作用。三种药物 PEG 的固体分散物能明显地增加药物的溶出速率,且随 PEG 的用量增加而增加,提示大多数水溶性差的药物可用固体分散法来增加药物的释放速率。但这种剂型和常用剂型的生物利用度的比较有待进一步研究。三种药物的 PVP-25000共沉淀物和物理混合物经溶出速率的测定发现,3-乙基5-苯海因、香豆素的溶出速率增加;而呋喃妥因可能由于形成不溶性络合物、化学吸附、形成胶团、表面现象等原因使其溶出速率低于纯呋喃妥因。3-乙基5-苯海因溶出速率随 PVP 的用量增加而
The authors studied the solid dispersions of nitrofurantoin, ethotoin, and coumarin made with PEG-6000 and the dispersions made with PVP-25000 using infrared spectroscopy and thin-layer chromatography The rate of dissolution of the coprecipitate and the physical mixture and the drug-carrier interaction. Solid dispersions of three drugs, PEG, significantly increased drug dissolution rate and increased with increasing PEG dosage, suggesting that most poorly water-soluble drugs may use solid dispersion methods to increase drug release rates. However, the comparison between the bioavailability of this dosage form and the commonly used dosage forms needs to be further studied. The dissolution rate of PVP-25000 coprecipitate and physical mixture of the three drugs was measured and the dissolution rate of 3-ethyl 5-phenylhydantoin and coumarin was increased. However, due to the formation of insoluble complex, the chemical adsorption , The formation of micelles, surface phenomena and other reasons to make dissolution rate lower than pure nitrofurantoin. The dissolution rate of 3-ethyl 5-phenylhexenone increased with the dosage of PVP