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目的:研究多烯磷脂酰胆碱胶囊联合复方益肝灵胶囊治疗抗结核药物致肝损伤患者的临床疗效。方法:选取2014年4月到2015年4月我院收治的抗结核药物致肝损伤患者150例,按照随机数字表法将患者分为研究组和对照组,每组75例,两组均继续行抗结核治疗,对照组给予常规保肝药物治疗,研究组给予多烯磷脂酰胆碱胶囊联合复方益肝灵胶囊保肝治疗,比较两组临床疗效,治疗前后谷丙转氨酶(ALT)、谷草转氨酶(AST)以及r-谷氨酰转移酶(r-GT)。结果:研究组有效率为89.3%显著高于对照组的73.3%,两组比较差异具有统计学意义(P<0.05);两组治疗后AST、ALT以及r-GT显著低于治疗前,且治疗后研究组AST、ALT以及r-GT均显著低于对照组,比较差异均具有统计学意义(均P<0.05)。结论:多烯磷脂酰胆碱胶囊联合复方益肝灵胶囊治疗抗结核药物致肝损伤具有较好临床疗效,能增强对肝脏的保护作用。
Objective: To study the clinical efficacy of polyene phosphatidylcholine capsules combined with Yiganling capsule in the treatment of patients with liver injury caused by anti-tuberculosis drugs. Methods: From April 2014 to April 2015, 150 cases of liver damage caused by antituberculosis drugs in our hospital were selected. According to the random number table, the patients were divided into study group and control group, with 75 cases in each group. Both groups continued The patients in the control group were treated with conventional hepatoprotective drugs. The study group was given polyene phosphatidylcholine capsules in combination with Yiganling capsule for liver protection. The clinical efficacy of the two groups was compared. Before and after treatment, alanine aminotransferase (ALT) Aminotransferase (AST) and r-glutamyl transferase (r-GT). Results: The effective rate of the study group was 89.3%, which was significantly higher than that of the control group (73.3%), the difference between the two groups was statistically significant (P <0.05); AST, ALT and r- After treatment, the levels of AST, ALT and r-GT in the study group were significantly lower than those in the control group (all P <0.05). CONCLUSION: Polyene phosphatidylcholine capsules combined with Yiganling Capsule in the treatment of hepatic injury caused by anti-TB drugs have good clinical efficacy and can enhance the protective effect on the liver.