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Objective: The aim of this study was to evaluate clinical efficacy of nutritional therapy with Kabiven PI and ω-3 fish oil fat emulsion on advanced stage of malignant tumor. Methods: One hundred and fifity-seven patients with advanced stage of malignant tumor were performed parenteral nutrition and enteral nutritional adjunctive therapy with Kabiven PI and ECOG ≥ 3 of 103 cases, therapy interval 2-3 weeks, declined 1 score. 28 were performed with chemotherapeutics under nutritional therapy 2-4 periodical. 25 of 26 died were dead for cancer cachexia and multiple organ failure. Survival time was 2-7 months. No serious complications occurred in all patients. Conclusion: The symptom and quality of life of advanced stage of malignant tumor were obviously improve by nutritional therapy. The opportunity for therapy tumor was offered. It is a important method on combined therapy of malignant tumor.