帕金森病(Parkinson’s disease,PD)是中老年常见的神经变性疾病,呈渐进性进展,至疾病晚期将严重影响患者生存质量。它不仅表现有严重的运动功能障碍,还可伴有情感障碍,特别是抑郁症状,对患者有重要的影响[1]。PD伴发抑郁症状(PDD)的发生率国内外报道达50%～70%[2],是影响患者生活质量的重要因素。本文主要探讨帕金森病与抑郁的关系。 Parkinson’s disease (Parkinson’s disease, PD) is a common neurodegenerative disease in middle-aged and elderly patients, with progressive progress, to the late disease will seriously affect the quality of life of patients. It not only presents with severe motor dysfunction, but also with affective disorders, especially depressive symptoms, which have a significant impact on patients [1]. The incidence of PD with depressive symptoms (PDD) at home and abroad reached 50% to 70% [2], is an important factor affecting the quality of life of patients. This article focuses on the relationship between Parkinson’s disease and depression.