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目的观察肝细胞生长因子(hepatocyte growth factor,HGF)及其受体(c-Met)在小鼠肾发育中的时空性表达,探讨其与肾发育的关系。方法采用免疫组织化学技术结合体视学方法对不同胚龄及生后日龄小鼠肾组织HGF和c-Met的表达及其含量变化进行系统观察和定量分析。结果HGF和c-Met在各期的肾小体、皮质肾小管及集合管均有表达,且随胚(日)龄增加在各期肾小体、皮质肾小管及集合管的表达是先增后减。结论推测HGF和c-Met可能对肾各结构的发育以及成熟肾的形态维持起重要作用。
Objective To observe the spatiotemporal expression of hepatocyte growth factor (HGF) and its receptor (c-Met) in the development of the kidney of mice and to explore its relationship with the development of the kidney. Methods Immunohistochemistry and stereological methods were used to systematically observe and quantify the expression of HGF and c-Met in renal tissues of different age and postnatal mice. Results The expression of HGF and c-Met in renal tissues, cortical tubules and collecting tubes were all increased at each stage. The expression of HGF and c- Subtract. Conclusion It is speculated that HGF and c-Met may play an important role in the development of various structures of the kidney and the morphological maintenance of mature kidney.