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目的探讨高频振荡通气治疗新生儿持续肺动脉高压的疗效和安全性。方法对收治的63例新生儿持续肺动脉高压患儿的资料行回顾性分析,将其分为观察组(高频振荡通气)和对照组(常频机械通气),并对二组患儿的一般资料、疗效等数据行统计分析。结果二组比较,观察组羊水胎粪污染发生率较高;二组的胎粪吸入性肺炎差异有统计学意义(P<0.05);观察组肺动脉高压的程度较对照组重(P<0.05);观察组行机械通气后的血气分析结果较通气前明显改善(P<0.01);机械通气后二组比较,观察组的吸氧浓度更低(P<0.05);硫酸镁的使用率和合并颅内出血的比较,二组差异无统计学意义(均P>0.05);发生气胸且使用胸腔闭式引流的的比较,观察组较对照组低(P<0.05)。结论高频振荡通气治疗新生儿持续肺动脉高压疗效明显,且在发生气胸时能减少胸腔闭式引流的使用,治疗的同时不增加颅内出血的发生率,值得临床推广应用。
Objective To investigate the efficacy and safety of high-frequency oscillatory ventilation in the treatment of neonatal persistent pulmonary hypertension. Methods Data of 63 neonates with persistent pulmonary hypertension underwent retrospective analysis. The data were divided into the observation group (high-frequency oscillatory ventilation) and the control group (normal-frequency mechanical ventilation), and the data of two groups of children Data, efficacy and other data line statistical analysis. Results The incidence of meconium-stained amniotic fluid in the observation group was higher than that in the control group (P <0.05). The degree of pulmonary hypertension in the observation group was heavier than that of the control group (P <0.05) ; The results of blood gas analysis after mechanical ventilation in observation group were significantly improved compared with that before ventilation (P <0.01); the oxygen absorption of observation group was lower (P <0.05) in the two groups after mechanical ventilation; the utilization rate of magnesium sulfate Intracranial hemorrhage, there was no significant difference between the two groups (all P> 0.05). The incidence of pneumothorax and closed thoracic drainage was significantly lower in the observation group than in the control group (P <0.05). Conclusions High-frequency oscillatory ventilation is effective in treating persistent pulmonary hypertension in newborns, and can reduce the use of closed thoracic drainage when pneumothorax occurs. The treatment does not increase the incidence of intracranial hemorrhage and is worthy of clinical application.