阿司匹林具有抗血小板聚集的作用,用于心肌梗死和缺血性脑血管病的预防。但在长期随访中发现,应用阿司匹林治疗的冠心病病人仍有可能发生缺血性血管事件,也就是存在阿司匹林抵抗现象。虽然其发生机制尚不明确,但基因多态性与阿司匹林抵抗的发生有一定的关系。现就近年来关于阿司匹林抵抗与基因多态性关系的一些研究结果。 Aspirin has an anti-platelet aggregation effect for the prevention of myocardial infarction and ischemic cerebrovascular disease. But in the long-term follow-up found that aspirin-treated patients with coronary heart disease is still possible ischemic vascular events, that is, there is the phenomenon of aspirin resistance. Although its mechanism is not yet clear, but genetic polymorphism and aspirin resistance have a certain relationship. In recent years, on the relationship between aspirin resistance and genetic polymorphisms of some of the findings.