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目的 观察粒细胞集落因子在肝硬化失代偿中的意义。方法 117例肝硬化失代偿病人分别采静脉血清、腹水 ,用ELISA法检测GCSF ,同时查血常规及腹水培养。结果 肝硬化失代偿病人血清及腹水中GCSF水平均升高 ,两者阳性率均与原发性腹膜炎密切相关 ,有腹膜炎的病人血清GCSF阳性率达 10 0 % (P <0 .0 1) ,腹水GCSF阳性率达 83.33% (P <0 .0 0 1) ,两者阳性率有显著的一致性 (P <0 .0 1)。结论 对发热、细菌培养阴性、粒细胞性及低蛋白性腹水 ,在达不到传统确定腹腔感染指标时 ,血清及腹水中GCSF水平是一项敏感指标
Objective To observe the significance of granulocyte colony factor in decompensation of liver cirrhosis. Methods One hundred and seventy-seven patients with decompensated liver cirrhosis were enrolled in this study. Serum and ascites were collected respectively. GCSF was detected by ELISA, routine blood tests and ascites culture were performed. Results The serum levels of GCSF in serum and ascites of patients with decompensated liver cirrhosis were significantly higher than those of patients with primary peritonitis. The positive rate of GCSF in peritonitis patients was 100% (P0.01) , The positive rate of GCSF in ascites was 83.33% (P <0.01), the positive rates of GCSF were significantly consistent (P <0.01). Conclusions In the case of fever, bacterial culture negative, granulocytic and low protein ascites, the GCSF level in serum and ascites is a sensitive index when the traditional indicators of intra-abdominal infection are not reached