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目的:观察紫杉醇周方案治疗老年非小细胞肺癌的疗效及毒副作用。方法:将患者随机分为两组,治疗组23例,紫杉醇60m g/m2加入500 mL生理盐水静脉滴注3 h,每周1次;第2,5周联合应用顺铂50 m g/m2,分2~3 d加入500 mL生理盐水静脉滴注;对照组28例,紫杉醇150 m g/m2,加入500 mL生理盐水静脉滴注3 h,第1 d顺铂总量75 m g/m2,第1~4 d加入500 mL生理盐水静脉滴注。所有患者每周期21 d,2个周期后作疗效评价。结果:两组患者近期有效率(CR+PR)分别是47.83%(11/23)和32.14%(9/28)。两组无显著性差异(P>0.05)。治疗组骨髓抑制和外周神经毒性比例少,程度也轻;对照组抑制较多,程度重,两组有显著性差异(P<0.05),恶心呕吐、脱发、肝功异常、肾功异常两组发生率相当。结论:较传统用法,紫杉醇周方案治疗老年非小细胞肺癌能够提高有效率,且毒副反应轻,老年人可以耐受。
Objective: To observe the efficacy and side effects of paclitaxel regimen in the treatment of elderly patients with non-small cell lung cancer. METHODS: Patients were randomly divided into two groups. The treatment group consisted of 23 patients. Paclitaxel 60 mg/m2 was intravenously infused with 500 mL physiological saline for 3 h once a week, and cisplatin 50 mg/m2 was administered at 2 and 5 weeks. Intravenous infusion of 500 mL normal saline was added over 2 to 3 days; in the control group, paclitaxel 150 mg/m2, and 500 mL normal saline was intravenously infused for 3 h, the first day of total cisplatin 75 mg/m2, the first ~ 4 d intravenous infusion of 500 mL of saline. All patients were evaluated for efficacy after 21 days and 2 cycles. Results: The effective rate (CR+PR) of the two groups was 47.83% (11/23) and 32.14% (9/28), respectively. There was no significant difference between the two groups (P>0.05). In the treatment group, the proportion of myelosuppression and peripheral neurotoxicity was less, and the degree was lighter; the control group had more inhibition, and the degree was heavy. There was a significant difference between the two groups (P<0.05), nausea and vomiting, hair loss, abnormal liver function, abnormal renal function. The incidence is quite similar. Conclusion: Compared with traditional usage, paclitaxel-weekly regimen can improve the efficiency of elderly patients with non-small-cell lung cancer, and the side effects are mild, and the elderly can tolerate it.