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目的:探讨关节牵张成形术联用塞来昔布对创伤性踝关节炎患者软骨细胞代谢的影响。方法:抽取2018年12月至2019年10月济宁医学院附属湖西医院收治的创伤性踝关节炎患者96例，按照治疗方案分为两组，每组48例。对照组行关节牵张成形术，研究组行关节牵张成形术联用塞来昔布治疗。回顾性分析两组治疗效果及软骨细胞代谢指标。结果:研究组治疗后优良率为89.58%(43/48)，高于对照组的72.92%(35/48)，χn 2＝4.376，n P＝0.036。治疗后研究组骨钙素水平为(8.95±1.26)μg/L、骨特异性碱性磷酸酶水平为(58.24±10.33)U/L，高于对照组的相应值(n P<0.05)。治疗后研究组抗酒石酸盐酸性磷酸酶异构体水平为(3.38±1.95)U/L，低于对照组的相应值(n P<0.05)。n 结论:关节牵张成形术联用塞来昔布可改善软骨细胞代谢水平，促进骨形成。“,”Objective:To investigate the effect of distraction arthroplasty combined with celecoxib on chondrocyte metabolism in patients with traumatic osteoarthritis.Methods:A total of 96 patients with traumatic ankle arthritis admitted to the Huxi Hospital Affiliated to Jining Medical College from December 2018 to October 2019 were divided into two groups according to the treatment plan, with 48 cases in each group. The control group underwent distraction arthroplasty and the study group underwent distraction arthroplasty combined with celecoxib treatment.The treatment effect and chondrocyte metabolism indexes were analyzed retrospectively between the two groups.Results:The excellent and good rate after treatment in the study group was 89.58% (43/48), which was higher than 72.92% (35/48) in the control group, χ n 2=4.376, n P=0.036. After treatment, the level of bone gla protein in the study group was (8.95±1.26) μg/L, and the level of bone alkalin phosphatase was (58.24±10.33) U/L, which were higher than the corresponding values in the control group ( n P<0.05). After treatment, the tartrate-resistant acid phosphatase-5b level of the study group was (3.38±1.95) U/L, which was lower than the corresponding value of the control group (n P<0.05).n Conclusions:distraction arthroplasty combined with celecoxib can improve chondrocyte metabolism and promote bone formation.