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尿中邻甲酚(o-cresol)与甲苯暴露存在良好相关关系,是中低浓度甲苯接触的特异和敏感生物标志物。本文综述了尿中o-cresol作为职业接触甲苯的生物监测指标研究现状,介绍了国内外检测尿中o-cresol的各种方法。目前国内外研究检测职业接触甲苯的暴露标志物尿中o-cresol,多用气相色谱法(GC)、高效液相色谱法(HPLC)和气相色谱-质谱(GC/MS)等方法。
There is a good correlation between o-cresol and toluene exposure in urine and is a specific and sensitive biomarker for exposure to low and medium concentrations of toluene. This review summarizes the status quo of o-cresol in urine as a bio-monitoring indicator of occupational exposure to toluene and introduces various methods for detecting o-cresol in urine at home and abroad. At present, domestic and foreign research to detect occupational exposure to toluene exposure markers urinary o-cresol, multi-use gas chromatography (GC), high performance liquid chromatography (HPLC) and gas chromatography-mass spectrometry (GC / MS) and other methods.