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目的 分析骨样骨瘤全身骨显像(WBS)和SPECT/CT显像的图像特征.方法 回顾性纳入2010年1月至2018年12月间西南医科大学附属医院经病理证实且以局部疼痛为主要表现的70例骨样骨瘤患者(男50例,女20例,年龄4～66岁),分析患者99Tcm-亚甲基二膦酸盐(MDP)平面显像及SPECT/CT显像的图像特点.结果 WBS联合SPECT/CT显像发现70个病灶,以股骨(37.1％,26/70)和胫骨(35.7％,25/70)病灶多见;56例行三时相骨显像的患者病灶与健侧放射性比值(T/NT)为3.7±1.2.WBS示病灶摄取呈圆形(或类圆形)者48个(68.6％,48/70),呈梭形者21个(30.0％,21/70),不规则形状者1个(1.4％,1/70);SPECT/CT显像示病灶摄取呈圆形(或类圆形)者69个(98.6％,69/70),不规则形状者1个(1.4％,1/70).WBS中表现为“双灰度征”的病灶有48个(68.6％,48/70);而SPECT/CT显像示59个(84.3％,59/70)病灶表现为“双灰度征”.SPECT/CT显像示59个(84.3％,59/70)病灶有瘤巢,27个(38.6％,27/70)病灶出现钙化或骨化(即“靶征”).结论 骨样骨瘤的典型WBS及SPECT/CT显像征象包括“双灰度征”、瘤巢及“靶征”等,这些征象有助于骨样骨瘤的诊断.“,”Objective To analyze features of osteoid osteoma on whole-body bone scan (WBS) and SPECT/CT imaging.Methods From January 2010 to December 2018,70 patients (50 males,20 females,age:4-66 years) with osteoid osteoma confirmed by pathology were enrolled from the Affiliated Hospital of Southwest Medical University.All patients underwent WBS and SPECT/CT imaging and imaging features were retrospectively analyzed.Results A total of 70 lesions were found by WBS combined with SPECT/CT imaging,and 26 lesions (37.1％,26/70) were found in the femur and 25 lesions (35.7％,25/70) in the tibia.The radioactive ratio of target lesion to non-target lesion (T/NT) was 3.7±1.2 in 56 patients who underwent three-phase bone imaging.WBS showed that 48 lesions (68.6％,48/70) were round (or nearly round),21 lesions (30％,21/70) were spindle-shaped,and 1 lesion (1.4％,1/70) was irregular-shaped,while SPECT/CT imaging showed that 69 lesions (98.6％,69/70) were round (or round) and 1 lesion (1.4％,1/70) was irregular-shaped.The “double-density sign” was found in 48 lesions (68.6％,48/70) by WBS and in 59 lesions (84.3％,59/70) by SPECT/CT imaging.SPECT/CT imaging detected nidus in 59 lesions (84.3％,59/70) and calcification or ossification (“target sign”) in 27 lesions (38.6％,27/70).Conclusion The typical features of osteoid osteoma on WBS and SPECT/CT imaging include “double density sign”,nidus and “target sign”,which contribute to the diagnosis of osteoid osteoma.