目的　讨论喉颗粒细胞瘤的组织发生、形态学特点和生物学行为。方法　报道 3例喉颗粒细胞瘤并进行组织形态学、组织化学及免疫组织化学染色研究 ,结合文献对本病的诊断标准、鉴别要点及组织来源进行探讨。结果　喉颗粒细胞瘤组织学形态特点与其他软组织颗粒细胞瘤基本一致 ,但 5 0 %～ 6 0 %伴有肿瘤表面鳞状上皮呈假上皮瘤样增生。免疫组化S 10 0、Vimentin、CD6 8、MBP等在肿瘤细胞胞浆内呈阳性表达 ,PAS染色中胞浆为阳性反应。结论　发生于喉部的颗粒细胞瘤为罕见肿瘤 ,通常为良性肿瘤 ,采用局部切除法治疗 ,预后好。多数学者认为该肿瘤起源于雪旺细胞 Objective To discuss the histopathology, morphological characteristics and biological behavior of laryngeal granulosa cell tumor. Methods Three cases of laryngeal granulosa cell tumor were reported and studied by histomorphometry, histochemistry and immunohistochemical staining. The diagnostic criteria, identification points and sources of the disease were discussed in combination with the literature. Results The morphology of laryngeal granulosa cell tumor was basically the same as that of other soft tissue granulosa cell tumors. However, the surface epithelial squamous cell carcinoma showed pseudopothelioma hyperplasia from 50% to 60%. Immunohistochemistry S 10 0, Vimentin, CD6 8, MBP and other positive expression in the cytoplasm of tumor cells, PAS staining cytoplasm positive. Conclusions Granulosa cells occur in the larynx as rare tumors, usually benign tumors. They are treated by local excision and the prognosis is good. Most scholars believe that the tumor originated in Schwann cells