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目的:探析纳洛酮联合无创正压机械通气(NIPPV)治疗慢性阻塞性肺疾病(COPD)伴Ⅱ型呼吸衰竭的疗效及安全性。方法:随机抽取我院收治的COPD合并Ⅱ型呼吸衰竭112例为研究对象,采用随机数字法将其随机分为对照组和治疗组,每组56例,对照组在临床常规综合治疗基础上给予NIPPV,治疗组在此基础上给予纳洛酮,观察两组患者肺功能和血气指标改善情况,对比分析疗效及不良反应发生情况。结果:两组患者治疗后肺功能和动脉血气指标明显改善(P<0.05),治疗组改善情况更为明显(P<0.05);治疗组总有效率为94.64%明显高于对照组的80.36%(P<0.05),两组均为发生严重的不良反应。结论:洛酮联合无创正压机械通气能有效改善慢性阻塞性肺疾病合并Ⅱ型呼吸衰竭患者的肺功能和血气指标,疗效显著,不良反应低,安全性高,值得在临床上广泛推广和应用。
Objective: To investigate the efficacy and safety of naloxone in combination with noninvasive positive pressure mechanical ventilation (NIPPV) in the treatment of chronic obstructive pulmonary disease (COPD) with type Ⅱ respiratory failure. Methods: A total of 112 COPD patients with type Ⅱ respiratory failure admitted to our hospital were randomly selected as the research object. Randomly divided into control group and treatment group, 56 cases in each group. The control group was given on the basis of routine clinical treatment NIPPV, the treatment group was given naloxone on this basis, to observe the two groups of patients with pulmonary function and blood gas index improvement, comparative analysis of the efficacy and adverse reactions. Results: The pulmonary function and arterial blood gas index of two groups were significantly improved (P <0.05), and the improvement of the treatment group was more obvious (P <0.05). The total effective rate of the treatment group was 94.64%, significantly higher than that of the control group (80.36% (P <0.05), both groups were serious adverse reactions. Conclusion: Combined with noninvasive positive pressure mechanical ventilation, losartan and noninvasive positive pressure mechanical ventilation can effectively improve pulmonary function and blood gas index in patients with chronic obstructive pulmonary disease and type Ⅱ respiratory failure, with significant curative effect, low adverse reactions and high safety, which is worthy of widespread application in clinic .